Treating Psoriatic Arthritis with Umbilical Cord Tissue Mesenchymal Stem Cells
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Psoriatic arthritis is the name of a type of arthritis that develops in patients who suffer from the skin condition psoriasis. It is a chronic condition, meaning that it will usually last for the rest of a patient’s life. This inflammatory condition generally affects any joint in the body but most commonly affects the joints of the hands and feet.
Patients who suffer from psoriatic arthritis often experience pain, stiffness, and swelling in their joints, which can be intermittent or permanent. The symptoms of psoriatic arthritis can vary from mild to severe. There is no cure for psoriatic arthritis. However, there are treatments that can help manage the symptoms and slow the progression of the disease, and help to provide some relief for patients.
How Many People Have Psoriatic Arthritis?
According to statistics, about 2.5 million Americans currently suffer from psoriatic arthritis. Across the globe, 125 million people have been diagnosed with psoriasis. This accounts for around 3% of the entire world population.
In the United States, approximately 30% of patients who suffer from psoriasis also have psoriatic arthritis. Globally, around 37.5 million people suffer from this chronic condition.
What are the Symptoms of Psoriatic Arthritis?
This chronic disease presents itself in a variety of symptoms and signs in patients. In many cases, the disease continues to worsen over time. There are also instances where patients experience periods of improvement or times when symptoms disappear temporarily.
People who suffer from psoriatic arthritis often experience problems in the joints on one or both sides of their bodies. There are various symptoms of psoriatic arthritis that resemble those of rheumatoid arthritis. In addition to joint pains, this condition is more likely to cause various other symptoms, including:
- Lower back pain, such as the development of spondylitis
- Nail changes (dents, crumbling, or even separation)
- Foot pain in the areas near ligaments and tendons, particularly in the back of the heel or the soles of the feet
- Eye inflammation, like uveitis, that can cause redness, pain, and blurry vision
- Swollen toes and fingers that can appear sausage-like and be painful
Unfortunately, there is no cure for psoriatic arthritis. However, there are various treatments that can help patients alleviate some of the symptoms that they experience as a result of this condition.
What Treatment Options are Available for Psoriatic Arthritis?
There is currently no cure for psoriatic arthritis. However, there are several treatment options available to help patients alleviate some of the symptoms that they experience due to this debilitating condition.
One of the most common types of treatment provided to patients is medications. Doctors routinely prescribe nonsteroidal anti-inflammatory drugs or NSAIDs. These medications are effective in alleviating some of the pain that patients experience in reducing inflammation for people who suffer from mild symptoms.
In addition, conventional DMARDs (disease-modifying antirheumatic drugs) are given to patients in order to slow the progression of their disease. These medications can also help to save some of the joint tissues and other tissues that are affected by psoriatic arthritis from permanent damage. Methotrexate is one of the most commonly prescribed medications for patients who suffer from this condition..
Another common treatment option is targeted synthetic DMARDs. These medications can be used if the biologic agents in conventional DMARDs are ineffective. Regrettably, higher doses of this type of medication can increase the chances of patients experiencing severe blood clots.
Biologic agents are sometimes prescribed to help people get some relief from their symptoms. These medications are designed to target various areas of the body in order to help reduce some of the symptoms that affect the immune system of patients
Finally, newer oral medications have been prescribed to patients that are designed to decrease some of the activity of the enzymes in the body that can typically cause inflammation within cells. These medications are designed to provide some relief to patients.
In addition to medications, therapies may be utilized to help provide patients with some relief and to teach them adapted ways to perform various tasks when they are unable to do so normally due to their condition.
Surgeries may be utilized in the form of steroidal injections and joint replacement surgeries. However, these are typically only used in severe cases.
More recently, scientists have begun to utilize umbilical cord-derived mesenchymal stem cells to provide significant relief for patients who suffer from psoriatic arthritis. The results so far have been very promising.
What are Umbilical Cord-Derived Mesenchymal Stem Cells?
Umbilical cord-derived mesenchymal stem cells, also known as UC-MSCs, are a type of adult stem cell that is extracted from within the umbilical cord.
UC-MSCs are incredibly unique due to the fact that they have the ability to differentiate into multiple cell types. These include:
- Osteocytes,
- Chondrocytes
- Adipocytes
- Myocytes
In addition, umbilical cord mesenchymal stem cells are known to promote tissue repair and regeneration in the body. They also have anti-inflammatory properties, which is useful for a wide range of diseases and conditions. Overall, these stem cells have great potential for use in the treatment of a variety of diseases, including psoriatic arthritis.
Theories Behind the Use of UCT-MSCs for Psoriatic Arthritis Relief
One of the features that makes umbilical cord tissue mesenchymal stem cells truly unique is the fact that they have strong anti-inflammatory characteristics. They are also able to regenerate a variety of types of damaged cells and tissues. For this reason, it only makes sense that UC-MSCs would be effective when it comes to treating conditions like psoriatic arthritis.
Due to the fact that umbilical cord tissue mesenchymal stem cells are effective in reducing inflammation in the body, it can be expected that these cells would be effective in reducing the inflammation that is experienced by sufferers of psoriatic arthritis. Additionally, it can help to regenerate tissues that have been damaged as a result of psoriatic arthritis. This combination seems very effective when it comes to providing relief to patients who suffer from this debilitating condition. Due to the fact that there is currently no cure for psoriatic arthritis, many scientists are considering whether or not these types of stem cells will be relevant in the future of treating this type of condition.
In recent years, there have been several scientific studies on the use of these stem cells for treating psoriatic arthritis that have proven promising, raising the possibility of a revolutionary new treatment in the future.
Studies on the Use of UCT-MSCs for Treating Psoriatic Arthritis
According to recent studies, the use of UCT-MSCs (umbilical cord mesenchymal stem cells) shows incredible promise for treating psoriatic arthritis. This form of arthritis is characterized by inflammation of the joints and skin, so the anti-inflammatory properties of the umbilical cord mesenchymal stem cells offer more effective treatment than anything we have been prescribing up until now.
A good example is the case of a 47-year-old man who had suffered from this condition since 1995. He has tried numerous treatments over the years, but none of them provided lasting relief. After being given three rounds of minimally manipulated UC-MSCs, his skin cleared up within three months, and he has been free from psoriasis ever since. Other cases have reported similar positive results with no recurrences.
Patients who received a UC-MSC infusion showed significant improvements in symptoms compared to those who did not receive the treatment. There was also a reduction in the levels of pro-inflammatory cytokines, which are the molecules that contribute to inflammation.
Studies involving mice injected with imiquimod-induced psoriasis-like skin inflammation have revealed promise. The study found that mesenchymal stem cell injection caused a dramatic reduction in IMQ-induced psoriasis severity, as interleukin-17-producing γδ T cells were inhibited. These observations indicate a potential form of treatment for psoriasis patients worldwide.
Another study on the use of UC-MSCs for psoriasis patients provided promising results as well. The study described two patients who suffered from psoriasis that were infused with autologous ADSCs. These were obtained through enzymatic indigestion and centrifugation of lipoaspirates as well as subsequent plating. One patient was provided two doses, while the second required three. Both of the patients showed significant improvement.
The results of these and other scientific studies that have been conducted over the past decade have provided valuable insight concerning the use of these stem cells. Providing relief to people who suffer from both psoriasis and psoriatic arthritis is always the goal of medical providers, especially when there is no cure. The prospect of these stem cells having the power to, in some cases, completely reverse symptoms of psoriatic arthritis is incredibly encouraging.
Fortunately, evidence shows that umbilical cord tissue-derived mesenchymal stem cells can be a potentially viable solution for treating psoriatic arthritis. The use of this novel and revolutionary technology has been effective in showing a reduction in inflammation, improved joint function and mobility, and increased quality of life in clinical studies. Although more research is needed in order to fully understand the potential implications of using umbilical cord tissue mesenchymal stem cells to treat psoriatic arthritis, the available evidence shows that it could be an effective way for those living with this condition to manage their symptoms and enjoy a better life.
Don’t wait to experience the benefits of advanced stem cell therapies. Contact Cellebration Wellness at 1.800.601.8290 today!
